We report a case of body stalk anomaly which was diagnosed at 12 weeks of gestation on a first trimester scan. The fetus displayed multiple anomalies characteristic of body stalk syndrome including abdominal wall defect, kyphoscoliosis, deformities of the lower limbs and a single umbilical artery. Body stalk anomaly is a rare congenital anomaly with a series of similar clinical manifestations and poor prognosis. The first trimester scan can estimate the risk for chromosomal abnormalities and may also reveal major congenital abnormalities.